Welcome to Take on Duchenne

Duchenne muscular dystrophy (DMD) is a severe, progressive and rare genetic childhood muscle-wasting disease1–4 where achieving a timely diagnosis is critical to delay disease progression and maintain quality of life.

This website provides educational resources to support healthcare professionals recognise the early signs and symptoms of DMD, diagnose and help manage patients in clinical practice. Here you will also find support materials and resources for your practice and for your patients.

1. McDonald CM, et al. Muscle Nerve. 2013:48;343–356.
2. Goemans N, et al. Eur Neurol Rev. 2014:9;78–82.
3. van Ruiten HJ, et al. Arch Dis Child. 2014;99:1074–1077.
4. Birnkrant DJ, et al. Lancet Neurol. 2018:17;251–267.

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Diagnosis
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Burden
Muscular dystrophy
Neuromuscular disorders
Management
Pharmacological therapy
Carriers
Genetic testing
Diagnosis; Creatine kinase (CK)
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Patients
Resources
Creatine kinase (CK)
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HCP resources
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Dystrophin
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Pathophysiology
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Children demonstrating red flag signs and symptoms such as significant development delay could have Duchenne  muscular dystrophy

References

Birnkrant DJ, et al. Lancet Neurol. 2018;17:251–267. National Task Force for Early Identification of Childhood Neuromuscular Disorders. Guide for primary care providers. Available at: https://childmuscleweakness.org/wp-content/uploads/2019/05/PrimaryCareProviderPacket.pdf [last accessed November 2020].
 

Expert insights: Dr Luca Bello's expert opinion on identifying the key signs and symptoms of Duchenne muscular dystrophy

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Learn about a mother's account of family life after receiving a Duchenne muscular dystrophy diagnosis for her son

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Expert insights: Dr Luca Bello's expert opinion on reaching a Duchenne muscular dystrophy diagnosis from initial suspicion

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Signs and symptoms: Recognising the early signs and symptoms of Duchenne muscular dystrophy

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Duchenne muscular dystrophy: Learn what Duchenne muscular dystrophy is and how it progresses

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Genetic counselling offers many benefits for families living with Duchenne muscular dystrophy

References

Helderman-van den Enden AT, et al. Clin Genet. 2011;79:236–242

Neuromuscular disorders: Learn about signs, symptoms and causes

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Neuromuscular disorders: An introduction

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Expert insights: Dr Damjam Osredkar's expert opinion on diagnosis and management of Duchenne muscular dystrophy

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Carrier testing: Learn about the importance of carrier screening

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Diagnosis: Learn about the importance of early diagnosis

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GPs are a first point of contact for concerned parents and they can be a driving force behind a successful diagnostic journey

References

Birnkrant DJ, et al. Lancet Neurol. 2018;17:445–455. Noritz GH, et al. Pediatrics. 2013;131:e2016–e2027.

Neuromuscular disorders: Learn about the 'red flag' signs and symptoms

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Patient resources: a variety of educational materials designed for patients and families

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Expert insights: Prof. Ros Quinlivan's expert opinion on Duchenne muscular dystrophy symptoms, diagnosis and management

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Genetic diagnosis: Learn about the importance of genetic testing in diagnosis

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Creatine kinase (CK): A guide to CK testing and interpreting the results

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Early signs and symptoms of Duchenne muscular dystrophy may appear before a child's second birthday

Neuromuscular disorders: What to do if you suspect a neuromuscular disorder

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RCPCH e-Learning module: Recognising neuromuscular disorders

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Meetings and events: Upcoming International (or local) Congresses and Events

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Educational materials: Comic books for children and caregivers explaining Duchenne muscular dystrophy

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Online resources: Find out more about educational websites for patients and families

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Duchenne muscular dystrophy is a rare genetic disorder that causes progressive muscular damage and degeneration

References

Van Ruiten HJ, et al. Arch Dis Child. 2014;99:1074–1077. 2. Birnkrant DJ, et al. Lancet Neurol. 2018;17:251–267.

Publications: Read some of the latest scientific and clinical research on Duchenne muscular dystrophy

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HCP resources: Duchenne muscular dystrophy materials for your practice

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Expert insights: Listen to Dr Luca Bello's expert opinion on reaching a diagnosis and managing Duchenne muscular dystrophy

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HCP resources: International Duchenne Care Considerations

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Pharmacological therapy: Learn more about treatment with glucocorticoids

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Duchenne muscular dystrophy is one of the most common and severe forms of muscular dystrophy  

References

National Institutes of Health. Muscular dystrophy. Available at: https://www.nichd.nih.gov/health/topics/factsheets/540 [last accessed November 2020]. Van Ruiten HJ, et al. Arch Dis Child. 2014;99:1074–1077.

Duchenne muscular dystrophy (DMD) management: Learn more about pharmacological treatments in the management of DMD

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Aetiology and genetics: Learn how Duchenne muscular dystrophy is inherited

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Aetiology and genetics: Learn what types of mutations cause Duchenne muscular dystrophy

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Aetiology and genetics: Learn what causes Duchenne muscular dystrophy

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Carriers of Duchenne muscular dystrophy: Learn about symptoms and care

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Duchenne muscular dystrophy is a progressive disease that presents in early childhood and requires an accurate and early diagnosis to avoid life-threatening complications

References

Birnkrant DJ, et al. Lancet Neurol. 2018;17:251–267.

Aetiology and genetics: Learn how common Duchenne muscular dystrophy is

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Find out which clinical specialties are involved in a Duchenne muscular dystrophy care team

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Duchenne muscular dystrophy management: Read bitesize summaries of standard of care guidelines

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Genetic counselling: How it can help families affected by Duchenne muscular dystrophy

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