How common is Duchenne muscular dystrophy (DMD)?

DMD is an x-linked recessive disorder that primarily affects males.1,2 While a rare disease, it is the most prevalent of all neuromuscular disorders, affecting 1 out of every 3,600–6000 newborn males worldwide.2-4

If a female carries the mutation in the dystrophin gene on one of the two X-chromosomes, she may also be affected by DMD. Approximately 10% of female carriers show some disease manifestations, with cardiac involvement a frequent finding.2,5

Adapted from MDA6

Duchenne muscular dystrophy primarily occurs in males, but can affect females in some cases.1,2 Learn about carriers of Duchenne muscular dystrophy; symptoms and care here.

1. Birnkrant DJ, et al. Lancet Neurol. 2018;17:251–267 [Part 1].
2. Bushby K. et al. Lancet Neurol. 2010;77–93.
3. van Ruiten HJ, et al. Arch Dis Child. 2014,99:1074–1077.
4. National Institutes of Health. Muscular dystrophy. Available at: https://www.nichd.nih.gov/health/topics/factsheets/540 [last accessed November 2020].
5. Florian A, et al. Eur Heart J Cardiovasc Imaging. 2016;17:326–333.
6. MDA. DMD muscular dystrophy (DMD): causes/inheritance. Available at: https://www.mda.org/disease/DMD-muscular-dystrophy/causes-inheritance [last accessed November 2020].
7. Ciafaloni E, et al. J Pediatr. 2009;155:380–385.
8. Dent KM, et al. Am J Med Genet. 2005;134:295–298.
9. DFSG. Carriers of Duchenne/Becker muscular dystrophy. Available at: https://www.dfsg.org.uk/understand-dmd/carriers-of-duchennebecker-muscular-dystrophy/ [last accessed November 2020].

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